450's don't care much for straight out exhaust, they tend to fry the exhaust cam and valves, and they're kind of hard to tune, the bike likes some back pressure to "work against".
You may want to consider putting some kind of muffler on it, just to give the engine a break.
And your ears too - it will be
very loud, like a DC-3 on takeoff.
Or if you can afford it, a tuned megaphone or something.
The carbs are very forgiving, but with pods and straight pipes, re-jetting may be indicated, you'll just have to see.
Best to avoid it if possible, as the 450 needles are not adjustable, which is something you often need to adjust when rejetting.
450 carbs are the definition of simplicity, just a few parts..
Take them apart and give a good soak in a gallon can of carb cleaner, then clean them up real good.
Use lots of compressed air.
DO NOT soak the slide needles, as they have a nylon thing on the end.
DO NOT soak the vacuum domes, same reason.
On both the choke and throttle flipper, there are nylon washers and stuff, so that all has to be taken apart.
Or alternately, if they're not too bad, just spray with a can of acetone type carb cleaner and use lots of compressed air, without taking all the shafts apart. See if they pass the "straw test".
Find out what size the jets are right now - let us know that, as well as the engine number.
There's a thread here about 450 carb setup, in the 450 section.....
http://www.hondatwins.net/forum/viewtopic.php?f=29&t=537